The science of painkillers as explained by Aussie scientist, Dr Karl Kruszelnicki

Chronic aches and pains are a bother for everyone, especially as we get older. Whether it’s caused by surgery, an injury, or an underlying health problem, managing the pain gets a little bit tricky with age.

The good news is painkillers are readily available at the local chemist, just be sure to get one that’s safe for you to take and has been approved by your GP.


While on the subject of painkillers, isn’t it amazing how the medicine just ‘knows’ where to go? How does it target the pain in our bodies, anyway? Well, popular Aussie scientist, Dr Karl Kruszelnicki discussed this in a TikTok video a couple of days ago, if you’d like to watch it, we’ve popped the video below!



Dr Karl explained how painkillers, such as ibuprofen and paracetamol, ‘find’ the pain in your body and temporarily stop it. He starts by saying that when his daughter was little, she asked him ‘how does the medicine know where it hurts so it can go there and fix it?’ Dr Karl explained that painkillers actually do not know.

Lm4jdbPwDOrg80fy6D3Q4HQlZ4DEBy71CN-UHPQJC-LcVsAOndbKAXva6fUScGVi0RjvO3BoGlVF0lY8YAF8KT3A0i3qR3adQRb8u7CjUOtJEVaq-tXetubkw3ZjOpp-1e_mQkq-6wBr0b9Nu18OW6kf26in9Vp2s7cicFooyiWPsyy5hcpUedoTxw

Dr Karl explains how painkillers ‘find the pain’ in our bodies. Credit: Daily Mail.

He also said that after getting injured, chemicals known as prostaglandins are created by the body. While prostaglandins also have healing effects, these chemicals cause pain and inflammation in injured areas.

Dr Karl gave Nurofen, a pain killer for adults, as an example of how painkillers work. ‘It blocks certain enzymes and pathways that stop prostaglandins from being made. Fewer prostaglandins, less pain.’ The doctor explained. He took the discussion further and provided a scenario for the viewers.

‘If you have a sore foot,’ he said, ‘Nurofen doesn’t magically travel only to your foot and start working there. Instead, the medicine travels all over your body to block prostaglandin pathways everywhere.’ Dr Karl explained that it is through this process, the medicine can stop the pain in the area.


He mentioned that side effects from medicinal intake happen because the medicine travels all over the body. Dr Karl also warned that Nurofen also blocks the body’s production of prostaglandins in our stomach. ‘Which is why,’ he explained, still referring to Nurofen, ‘That long-term use can cause stomach ulcers.’

By the end of the video, the celebrity scientist reiterated that medicine doesn’t mysteriously ‘travel’ to certain areas of our body. Instead, it has effects all over the body.

Qo1yAmTm_rmmkE7TF3mx681YnfVCrkMo6JvYb8upKaPUny1ZGs0ZBdoUMZLMYZCAIhSrLT0quTLCzB8tyeAYG9AS6kfoErPGzrCdJgpHBuYw-sB0JfBmYxbcWakhPmt3OmBfYDAVmVAkvREnWwxD0hFY81JW5QKxSHbck1kzM74R5mSYf34r5LpEkQ

Dr Karl warns that overuse of painkillers can lead to stomach ulcers. Credit: JESHOOTS.com from Pexels.

Dr Karl’s TikTok video has since garnered 32,000 views, with many people thanking him for his concise explanation. One person commented: ‘It wouldn’t matter if you had 2 or 3 different sore bits. It would just be as effective.’ Dr Karl affirmed this statement. ‘I reckon so – if all painful bits of your body had the same level of pain.’

One user asked, ‘What about antibiotics? Legit question.’ The popular doctor replied that ‘Antibiotics spread through the whole body – but kill bacteria only where the bacteria are.’

While another curious person asked, ‘Why does blocking prostaglandin in your stomach cause ulcers…?’ Dr Karl explained that ‘Prostaglandins have different actions that reduce the mucus layer, which stops stomach acids from dissolving the stomach wall.’


So, there you have it! What a great fun fact to learn, courtesy of Dr Karl Kruszelnicki. If you had the chance to ask the celebrity doctor himself, which questions would you ask? Do you have any more questions about which painkillers are safe to use for seniors? Perhaps more lessons on how certain medicines can affect your body? We want to hear your thoughts so comment down below!
 
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I'm 76 and haven't taken any painkiller since the early 1990s so I really wouldn't have any questions for the doctor. Maybe he'd like to ask me a few?
 
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Chronic aches and pains are a bother for everyone, especially as we get older. Whether it’s caused by surgery, an injury, or an underlying health problem, managing the pain gets a little bit tricky with age.

The good news is painkillers are readily available at the local chemist, just be sure to get one that’s safe for you to take and has been approved by your GP.


While on the subject of painkillers, isn’t it amazing how the medicine just ‘knows’ where to go? How does it target the pain in our bodies, anyway? Well, popular Aussie scientist, Dr Karl Kruszelnicki discussed this in a TikTok video a couple of days ago, if you’d like to watch it, we’ve popped the video below!



Dr Karl explained how painkillers, such as ibuprofen and paracetamol, ‘find’ the pain in your body and temporarily stop it. He starts by saying that when his daughter was little, she asked him ‘how does the medicine know where it hurts so it can go there and fix it?’ Dr Karl explained that painkillers actually do not know.

Lm4jdbPwDOrg80fy6D3Q4HQlZ4DEBy71CN-UHPQJC-LcVsAOndbKAXva6fUScGVi0RjvO3BoGlVF0lY8YAF8KT3A0i3qR3adQRb8u7CjUOtJEVaq-tXetubkw3ZjOpp-1e_mQkq-6wBr0b9Nu18OW6kf26in9Vp2s7cicFooyiWPsyy5hcpUedoTxw

Dr Karl explains how painkillers ‘find the pain’ in our bodies. Credit: Daily Mail.

He also said that after getting injured, chemicals known as prostaglandins are created by the body. While prostaglandins also have healing effects, these chemicals cause pain and inflammation in injured areas.

Dr Karl gave Nurofen, a pain killer for adults, as an example of how painkillers work. ‘It blocks certain enzymes and pathways that stop prostaglandins from being made. Fewer prostaglandins, less pain.’ The doctor explained. He took the discussion further and provided a scenario for the viewers.

‘If you have a sore foot,’ he said, ‘Nurofen doesn’t magically travel only to your foot and start working there. Instead, the medicine travels all over your body to block prostaglandin pathways everywhere.’ Dr Karl explained that it is through this process, the medicine can stop the pain in the area.


He mentioned that side effects from medicinal intake happen because the medicine travels all over the body. Dr Karl also warned that Nurofen also blocks the body’s production of prostaglandins in our stomach. ‘Which is why,’ he explained, still referring to Nurofen, ‘That long-term use can cause stomach ulcers.’

By the end of the video, the celebrity scientist reiterated that medicine doesn’t mysteriously ‘travel’ to certain areas of our body. Instead, it has effects all over the body.

Qo1yAmTm_rmmkE7TF3mx681YnfVCrkMo6JvYb8upKaPUny1ZGs0ZBdoUMZLMYZCAIhSrLT0quTLCzB8tyeAYG9AS6kfoErPGzrCdJgpHBuYw-sB0JfBmYxbcWakhPmt3OmBfYDAVmVAkvREnWwxD0hFY81JW5QKxSHbck1kzM74R5mSYf34r5LpEkQ

Dr Karl warns that overuse of painkillers can lead to stomach ulcers. Credit: JESHOOTS.com from Pexels.

Dr Karl’s TikTok video has since garnered 32,000 views, with many people thanking him for his concise explanation. One person commented: ‘It wouldn’t matter if you had 2 or 3 different sore bits. It would just be as effective.’ Dr Karl affirmed this statement. ‘I reckon so – if all painful bits of your body had the same level of pain.’

One user asked, ‘What about antibiotics? Legit question.’ The popular doctor replied that ‘Antibiotics spread through the whole body – but kill bacteria only where the bacteria are.’

While another curious person asked, ‘Why does blocking prostaglandin in your stomach cause ulcers…?’ Dr Karl explained that ‘Prostaglandins have different actions that reduce the mucus layer, which stops stomach acids from dissolving the stomach wall.’


So, there you have it! What a great fun fact to learn, courtesy of Dr Karl Kruszelnicki. If you had the chance to ask the celebrity doctor himself, which questions would you ask? Do you have any more questions about which painkillers are safe to use for seniors? Perhaps more lessons on how certain medicines can affect your body? We want to hear your thoughts so comment down below!

I inadvertently overdosed on Panadol when I got a virus a number of years ago but was also regularly taking Panadol Osteo and damaged my liver. Be very careful when pain persists or tablets don't seem to mask it anymore not to think it's ok to take more than recommended even for a few days. That's all it took to cause the damage. Also be aware that taking the painkillers and using pain reducing creams can also cause problems.
 
I've just about given up on painkillers, they no longer work for me. I have recently be prescribed Panadeine Forte, no relief, CBD oil, no relief, Morphine patches, no relief. I live with pain 24/7 and am waiting on surgery on my back so maybe that's where I'll get my relief. :(
 
I am super sensitive to the most simple of pain killers,
including analgesics like Panadol, Aspirin, Panadeine Forte, anti-inflammatories, Morphine patches have no effect. When I was waiting for a hip replacement for bone-on-bone pain, one Orthopod said my pain couldn't be too bad as I wasn't taking any analgesia.
(I get a deep stabbing pain in the epi-gastric area with these drugs.)
For years, bits of bone kept breaking off as the bones were rubbing together. It's only when I was changed Orthopedic Doctor that things got going, but due to the trauma incurred while waiting, the Operation caused more problems, and I cant drive anymore, and still cant take drugs for pain relief!
 

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