Is the popular weight loss drug Ozempic a risk to your mental health? Investigation demanded!

The quest for effective weight loss solutions often leads many to embrace new pharmaceutical options with open arms, but it's crucial to consider the potential side effects, especially when it comes to mental health. This is the current concern surrounding the popular weight loss drug Ozempic, known generically as semaglutide, which has recently come under scrutiny for its possible mental health risks.

International researchers are sounding the alarm and calling for a thorough investigation into the potential link between semaglutide and an increased risk of suicidal thoughts. This concern has emerged particularly among individuals who are already part of a vulnerable cohort due to existing mental health conditions.


Dr. Trevor Steward, an MRFF emerging leadership fellow from the University of Melbourne, highlighted the urgency of this issue. 'This analysis of a World Health Organization database suggests that people taking antidepressants may be more likely to report suicidal ideation when taking semaglutide,' he stated. The implications of these findings are significant, prompting discussions about whether additional precautions or warnings should be included on medication labels for patients with mental health issues.


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Researchers are investigating a potential link between the weight loss drug semaglutide and self-harm thoughts. Credit: Shutterstock


While the current data does not conclusively prove that semaglutide triggers an increase in dark thoughts compared to other diabetes and weight loss drugs, the call for further research is strong. There's a possibility that individuals without mental health conditions may not face the same risks, but as Dr. Steward emphasizes, 'more studies are needed to confirm this.'


Semaglutide works by inducing a feeling of fullness and suppressing appetite, which has led to its popularity as an off-label weight-loss treatment. The demand for the drug has skyrocketed, particularly in the United States, where clinicians wrote over nine million prescriptions for weight loss drugs like Ozempic in the last quarter of 2022 alone. This surge in interest has been fueled by celebrities and influencers who tout the benefits of such medications.

However, with this increased demand comes a responsibility to ensure patient safety. Novo Nordisk, the producer of Ozempic, has already indicated that supply will be limited in Australia for the remainder of the year. This shortage has led to the use of alternatives, some of which are replicas of Ozempic and Mounjaro, and there have been 'increasing reports of patients coming to harm,' according to the federal government.

Dr. Steward warns, 'The rise in off-label prescribing of these medications is concerning, and there is an urgent need for larger studies to understand any potential risks related to both the patient and the medication itself.' He urges consideration of factors such as the patient's motivations for using the medication, their history of mental health issues, and sociodemographic factors.


Interestingly, the potential mental health side effects of semaglutide drugs have been a topic of debate before. Some reports have even suggested that the drug could be linked to a lower risk of suicidal thoughts. However, these findings are not definitive, and regulatory bodies like the US Food and Drug Administration continue to investigate the matter, acknowledging that while preliminary evaluations have not found evidence of a causal relationship, they 'cannot definitively rule out that a small risk may exist.'

For our readers at the Seniors Discount Club, it's essential to approach new weight loss treatments with caution and to have open discussions with healthcare providers about the potential risks and benefits. If you or someone you know is considering semaglutide or similar medications, it's important to monitor mental health closely and seek professional advice if any concerns arise.

If you need help in a crisis, please call Lifeline on 13 11 14. For further information about depression, contact beyondblue at 1300224636 or talk to your GP, local health professional, or someone you trust.

Key Takeaways
  • International researchers have called for an investigation into a potential link between the weight loss drug semaglutide, sold as Ozempic and Wegovy, and thoughts of self-harm.
  • A World Health Organization database suggests that people taking antidepressants may be more likely to report suicidal ideation when also taking semaglutide.
  • Further investigation is needed to understand the potential risks, especially given the rising popularity of these medications due to off-label prescriptions for weight loss.
  • The US Food and Drug Administration has not found evidence that these medicines cause suicidal thoughts or actions but continues to investigate as they cannot rule out a small risk.
We invite you to share your thoughts and experiences with weight loss treatments and mental health in the comments below. Your insights could be invaluable to others in our community who are navigating similar decisions.
 

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I was prescribed ozempic for diabetes control. It certainly helped to bring blood sugar down. However, I could not shake nausea and vomiting that it caused. Had to discontinue and use insulin which has helped without causing nausea. I have never been overweight but still have diabetes!
 
I was prescribed Ozempic for uncontrolled diabetes. Take insulin twice a day but had bad problems with high sugar levels that insulin was not fixing. Insulin was being increased on a regular basis. My GP started me on Ozempic,didn't know it was a weight loss drug but my sugars came down and after a while my insulin was decreased. Yes I have lost weight and am happy with that and also with the drop in my sugar levels and insulin
 
I was prescribed Ozempic for my Type 2 Diabetes. I was surprised when the nurse who was instructing me how to inject told me she was on it too to lose weight. Consequently there was a shortage of the drug. However I found that I was becoming extremely nauseous and started vomiting to the extent that I had tostop taking it. I think that it is not right that people are viewing this as a weight losing drug and it’s consequently causing a shortage for those who need it for Diabetes medication
 
My sister who has diabetes has lost nearly 50kg on Ozempic and her friend has also. The friend has lost her sleep apnoea. It's an amazing drug as long as the patients are screened and monitored well by their GP. Nausea etc often resolves. I have not had any patients who have become depressed etc. There is also Wegovy coming out just for obesity but it's very expensive. BTW I lost 38 kg with no drugs, just sensible diet. My sister and I have had to throw out most of our clothes and get new ones.
 
Quick weight loss is never good. These new quick fixes. Mmmm when you come off the meds you gain the weight and more.
These drugs have to mix with the brain chemicals to make you feel full. If you are on antidepressants they work on the chemicals in the brain too. Recipe for disaster.
I just wish people could accept what their body shape is. Just try eat well enjoy a little luxury foods now and again and do a bit of exercise each day. It's great for the mind. We are not all meant to be slim. A bit of extra weight l would rather have and not feel like l don't want to be here. If anyone is struggling l have found Life Line are fantastic.
Kind regards to all Vicki
 

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