Are your medicines working as intended? Overuse of this common drug could lead to more problems

As we age, managing pain becomes a part of many of our daily routines.

Whether it's the aches of arthritis or the pains from past injuries, reaching for a painkiller is a quick and easy solution.

However, a recent study raised a red flag over the regular use of a common household painkiller and its potential link to several health issues.


Researchers from the University of Nottingham have issued an urgent warning about the dangers of frequently using paracetamol.

Their extensive analysis tracked the health of over half a million individuals aged 65 and lasted for over two decades.

According to the research's findings, paracetamol has a 'dose-dependent' relationship with a number of digestive, heart, and kidney problems.


compressed-pexels-paracetamol.jpeg
Paracetamol is an over-the-counter medicine often used for flu and fever. Image Credit: Pexels/JE Shoots


The study's findings were particularly concerning for those prescribed with paracetamol twice within six months.

The said group had a significantly higher risk of developing stomach ulcers, heart failure, hypertension, and chronic kidney disease compared to their peers who did not use the medication as frequently.

The research also suggested that the more paracetamol a person consumes, the greater the chance of experiencing severe complications.


One of the examples could be a stomach ulcer bleeding or rupturing.

This is alarming news, especially considering that paracetamol is often prescribed to older individuals to help manage chronic conditions.

Around 90 per cent of people over the age of 75 regularly take paracetamol primarily to treat joint and bone pain.

Paracetamol is also often used to alleviate discomfort.

However, Professor Weiya Zhang, an epidemiologist at the University of Nottingham, urged patients to 'carefully consider' the frequency of their paracetamol intake.


Paracetamol, also known as acetaminophen, is one of the most widely used drugs globally.

Despite its popularity, evidence indicated that it has a 'minimal pain-relief effect' for long-term conditions such as osteoarthritis.

This has led health authorities like The National Institute For Health and Care Excellence to revise their guidelines for treating osteoarthritis.

Apart from painkillers, they have now started recommending exercise programmes as the first line of treatment and advised against the routine offering of paracetamol.

While paracetamol has a milder nature compared to non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, high doses could still irritate the upper gastrointestinal tract.

Additionally, excessive use of paracetamol has been linked to increased blood pressure and kidney damage.

Overdosing on the drug has also been the leading cause of acute liver failure.

The liver could get overwhelmed with excessive amounts of paracetamol, resulting in a toxic form of the drug that damages liver cells.


The damage paracetamol could cause to the liver has been likened to that caused by alcohol and hepatitis.

Health authorities advised that the maximum safe dose of paracetamol for adults is two 500 mg tablets or capsules four times per day.

People should not exceed eight tablets in 24 hours.

Liver Disease Specialist Dr Kenneth Simpson warned about 'staggered overdoses' that often happen to individuals who take slightly more paracetamol than recommended.

Overdosing on paracetamol could potentially lead to fatal consequences.

In light of these findings, it's essential to consult with a general practitioner about the safest and most effective pain management strategies.

Alternative treatments, such as physical therapy, exercise, and other pain relief methods, should be explored to minimise the risks associated with frequent paracetamol use.
Key Takeaways

  • Scientists warned against regular use of paracetamol due to links with several complications.
  • A study from the University of Nottingham found a dose-dependent relationship between paracetamol use and an increased risk of stomach ulcers, heart failure, hypertension, and chronic kidney disease.
  • Evidence suggested that paracetamol only offered minimal pain relief for long-term conditions such as arthritis and osteoporosis.
  • Health guidelines recommend exercise programmes as the first line of treatment for conditions like osteoarthritis rather than the routine offering of paracetamol.
Have you or someone you know experienced issues with regular paracetamol use? Share your experiences with paracetamol and your thoughts about this study in the comments below.
 

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My Mum committed suicide in September 2007 from a massive overdose of paracetamol.

It took her four days to die, lapsing in and out of consciousness and eventually succumbing to renal and hepatic failure.

She suffered from a rare and aggressive from of osteoporosis for a few years previously.

To rub salt in the wound, the totally inept NSW Police accused me of being behind her death.

Trouble is I was living in Bundaberg at the time, over 1200 km away from Mum when she overdosed in Sydney!
my thoughts as that would have been horrible to go through. 🌻
 
Well this morning I have just had my first 2 injections in my back to help with my severe stenosis....it's affected by damage to 4 of my lower back vertebrae and discs....all a result of a rollover car accident many years ago....I have to go back next week for 2 more sets of injections....these along with Norspan pain patches each week, plus other painkillers each day and night and Panadol Rapid up to 6 per day. It really is a proper pain most of the day and when trying to sleep at night time. I was previously on Pariet and Lyrica for years and prior to that oxycontin when it was in vogue some years ago. I'm really hoping that these injections help. I'm totally sick to death of it all, believe me.🤒:giggle:
 
Well this morning I have just had my first 2 injections in my back to help with my severe stenosis....it's affected by damage to 4 of my lower back vertebrae and discs....all a result of a rollover car accident many years ago....I have to go back next week for 2 more sets of injections....these along with Norspan pain patches each week, plus other painkillers each day and night and Panadol Rapid up to 6 per day. It really is a proper pain most of the day and when trying to sleep at night time. I was previously on Pariet and Lyrica for years and prior to that oxycontin when it was in vogue some years ago. I'm really hoping that these injections help. I'm totally sick to death of it all, believe me.🤒:giggle:
You poor thing I'll stop complaining right away. You sound so much worse than me.
 
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I also take 4 osteo panadol every day, for 2 years because of painful knees and osteoarthritis. I have had both knees replaced, one a partial reconstruction, the other a full reconstruction. I have been getting stomach pains almost every day so I am off to see my doctor again. I have had every test possible and they cannot find anything! All I get is that it is probably related to my diverticulosis but they are not really sure....
That's the same for me, 4 osteo panadol a day for years, and I have diverticulitis, I have a pain in my left side, the doctor said probably muscular and sent me for an x ray, nothing. Back to see the doctor in 2 weeks, see if we can get this sorted.
 
That's the same for me, 4 osteo panadol a day for years, and I have diverticulitis, I have a pain in my left side, the doctor said probably muscular and sent me for an x ray, nothing. Back to see the doctor in 2 weeks, see if we can get this sorted.
I have a doctors appointment on 10th Feb!
 
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My Mum committed suicide in September 2007 from a massive overdose of paracetamol.

It took her four days to die, lapsing in and out of consciousness and eventually succumbing to renal and hepatic failure.

She suffered from a rare and aggressive from of osteoporosis for a few years previously.

To rub salt in the wound, the totally inept NSW Police accused me of being behind her death.

Trouble is I was living in Bundaberg at the time, over 1200 km away from Mum when she overdosed in Sydney!
On April the 29th 2017 my son took an accidental Panadeine Forte overdose, per the Coroners report, he had a migraine and took about 20 pills then woke up during the night and took some more, he was addicted to them and they took his life so I know where you are coming from :cry:
 
I won't write down all of my ails but I take Panadol Osteo and when needed Brufen and Panadeine Forte.
My problem is it is showing on my liver tests even though I don't take them daily, only when needed.
But my doctor said that even though the liver can repair itself, I use to be a very heavy drinker, that may be the cause of the markers, although they haven't got any worse over the years since I gave up in 2003, I do try to be careful with the Paracetamol I take.
 
On April the 29th 2017 my son took an accidental Panadeine Forte overdose, per the Coroners report, he had a migraine and took about 20 pills then woke up during the night and took some more, he was addicted to them and they took his life so I know where you are coming from :cry:
Mum took the equivalent of 70 GRAMS of paracetamol in one sitting. That's nearly 150 standard 500 grams tablets!

Nobody at the hospital could (or was able to) tell me what the problem was. Only when I snooped at the medical record, I found out that her blood count had a SIX times the level that of a normal person that would have a poor prognosis without treatment. Hence her slow but eventual death.
 
I won't write down all of my ails but I take Panadol Osteo and when needed Brufen and Panadeine Forte.
My problem is it is showing on my liver tests even though I don't take them daily, only when needed.
But my doctor said that even though the liver can repair itself, I use to be a very heavy drinker, that may be the cause of the markers, although they haven't got any worse over the years since I gave up in 2003, I do try to be careful with the Paracetamol I take.
For this reason, I have not taken ibuprofen for over two years.
 
Well this morning I have just had my first 2 injections in my back to help with my severe stenosis....it's affected by damage to 4 of my lower back vertebrae and discs....all a result of a rollover car accident many years ago....I have to go back next week for 2 more sets of injections....these along with Norspan pain patches each week, plus other painkillers each day and night and Panadol Rapid up to 6 per day. It really is a proper pain most of the day and when trying to sleep at night time. I was previously on Pariet and Lyrica for years and prior to that oxycontin when it was in vogue some years ago. I'm really hoping that these injections help. I'm totally sick to death of it all, believe me.🤒:giggle:
i feel for you. I do hope you get relief. I know where you are coming from. enjoy my happy flower. 🌻
 
My Mum committed suicide in September 2007 from a massive overdose of paracetamol.

It took her four days to die, lapsing in and out of consciousness and eventually succumbing to renal and hepatic failure.

She suffered from a rare and aggressive from of osteoporosis for a few years previously.

To rub salt in the wound, the totally inept NSW Police accused me of being behind her death.

Trouble is I was living in Bundaberg at the time, over 1200 km away from Mum when she overdosed in Sydney!
What an awful tragedy to go through and deal with…….. and such suffering in your mum’s last days :confused:……. I have to say though that such painful body hurt is awfully hard to deal with, and at such times it’s very easy to take more pain killers than you should, just to get some relief. When you are older, pain becomes less tolerable than it used to be, and for me, reaching for the pain killers is preferable to going to exercise.
 
My Mum committed suicide in September 2007 from a massive overdose of paracetamol.

It took her four days to die, lapsing in and out of consciousness and eventually succumbing to renal and hepatic failure.

She suffered from a rare and aggressive from of osteoporosis for a few years previously.

To rub salt in the wound, the totally inept NSW Police accused me of being behind her death.

Trouble is I was living in Bundaberg at the time, over 1200 km away from Mum when she overdosed in Sydney!
How sad for you and your Mum
 
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My Mum committed suicide in September 2007 from a massive overdose of paracetamol.

It took her four days to die, lapsing in and out of consciousness and eventually succumbing to renal and hepatic failure.

She suffered from a rare and aggressive from of osteoporosis for a few years previously.

To rub salt in the wound, the totally inept NSW Police accused me of being behind her death.

Trouble is I was living in Bundaberg at the time, over 1200 km away from Mum when she overdosed in Sydney!
I am so sorry to hear about your pain.
It is hard enough to suffer the loss of a loved one, but to be treated in this manner was nothing short of criminal.
 
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Reactions: Veggiepatch

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