Navigating the world of medications can be a complex journey, especially as we age. While we often rely on various drugs to manage our health conditions, it's crucial to stay informed about their potential long-term effects. For our community at the Seniors Discount Club, understanding these implications is particularly important, given the increased risk of dementia associated with advancing age.


Recently, a board-certified anaesthesiologist from Los Angeles, Dr Zain Hasan, raised concerns on social media about the potential link between certain daily medications and an increased risk of developing dementia. Among these medications is a common household name: Benadryl.


Benadryl, known generically as diphenhydramine, is an over-the-counter antihistamine widely used to alleviate symptoms of allergies, hay fever, and the common cold. However, its convenience may come with a hidden cost. Dr Hasan warns that prolonged use of Benadryl and other anticholinergic drugs, which block the neurotransmitter acetylcholine, has been linked to dementia. Acetylcholine plays a vital role in muscle contractions and brain functions, including learning and memory.


The concern doesn't stop with Benadryl. Dr Hasan also highlighted the risks associated with other medications, such as certain opioids, proton pump inhibitors (PPIs) like omeprazole, benzodiazepines, and tricyclic antidepressants. These drugs, while effective for their intended uses, may have sedative effects on the brain or interfere with crucial neurological processes.

For instance, opioids, which are often used for pain relief and are a key component of anaesthesia, have been found to nearly double the risk of developing dementia within three to seven years post-surgery where anaesthesia is used. Benzodiazepines, prescribed for anxiety and sleep disorders, can numb the brain and potentially lead to dementia with long-term use.

Omeprazole, a medication used to reduce stomach acid, has been scrutinised for its potential to increase beta-amyloid in the brain, a protein buildup associated with Alzheimer's disease. While studies have produced mixed results, the possibility that PPIs could contribute to vitamin B12 deficiency and affect memory and cognitive function is a concern that cannot be ignored.


The conversation around tricyclic antidepressants is more nuanced, with inconsistent scientific evidence regarding their link to dementia. However, like Benadryl, they exhibit anticholinergic effects, which warrants caution.

Dr Hasan's advice to those taking these medications is clear: consult with your primary care doctor before making any changes to your medication regimen. It's essential to have an open dialogue about your concerns regarding dementia, especially if you're younger and facing the prospect of long-term medication use.

Watch Dr Hasan's video here:

For our senior community, this information is a reminder to be proactive about our health choices. Regularly reviewing your medications with your healthcare provider is a good practice, as is staying informed about the latest research and recommendations.


If you or a loved one are using Benadryl or any of the medications mentioned, consider discussing alternative options with your doctor. There may be safer alternatives available that can manage your symptoms without the added risk.

We encourage our readers to share their experiences and thoughts on this topic. Have you had discussions with your doctor about the long-term use of these medications? What alternatives have you explored? Your insights could be invaluable to fellow members of the Seniors Discount Club who are navigating similar health concerns.

Remember, your health and well-being are paramount. Staying informed and advocating for yourself is the best way to ensure a healthy future.