As we age, our bones can become more fragile, and the risk of osteoporosis increases. It's a condition that affects many Australians, particularly those over 60, and can lead to painful and debilitating fractures. To combat this, doctors often prescribe medications to strengthen bones, with Prolia being one of the most common treatments in Australia. However, some patients are raising concerns about the side effects of this drug, and the question of informed consent is coming to the forefront.

Patients have shared their experiences with ABC NEWS, expressing their worries about not being fully informed of the potential risks associated with Prolia. They've reported feeling pressured into taking the medication without a clear understanding of the serious side effects, which, although rare, can be life-altering.

The case of Tiffany May, a 59-year-old who suffered an atypical femoral fracture, is a stark example. Her injury, which resulted in her left femur being replaced with titanium, was initially thought to be the result of a high-impact trauma. However, it was later linked to her six-year use of Prolia, prescribed after an early onset menopause-induced osteoporosis diagnosis. This type of fracture is a known, albeit uncommon, side effect of the drug.

Prolia, a drug dedicated to treating osteoporosis, has had averse side effects on several patients. Image Credit: Prolia

Prolia's side effects don't stop there. Patients have reported osteonecrosis of the jaw, a condition where the bone tissue in the jaw dies, and a higher risk of vertebral fractures upon ceasing the medication. There's also a 'wicked rebound' effect, where stopping Prolia without additional preventative measures can lead to multiple spine fractures. This rebound effect was highlighted in a 2020 article co-authored by Professor Markus Seibel, which estimated that 80% of patients discontinuing Prolia were not given medication to protect against this risk.

Margaret Ryan, an 85-year-old Prolia user, experienced a severe side effect when she developed lower-stage osteonecrosis of the jaw, leading to intense pain and swelling. Like many others, she was not warned about this possibility and believes that patients should be better informed, much like the warnings provided on cigarette packaging.

The Royal Australian College of General Practitioners (RACGP) has updated its guidance, recommending alternative drugs for transitioning off Prolia. Anita Munoz from RACGP Victoria emphasised the importance of doctors briefing patients on the drug's side effects and the complications of stopping it.

Despite these concerns, medical professionals like Professor Seibel and Dr. Munoz stress that the side effects of Prolia are rare and that the risk of not treating osteoporosis is much higher. They caution patients against discontinuing their treatment without consulting their healthcare provider.

Australia's medical regulator, the Therapeutic Goods Administration (TGA), approved Prolia in 2010, noting its effectiveness in increasing bone mineral density and reducing fracture risk. The TGA and Amgen, the manufacturer of Prolia, maintain that they monitor and report adverse events and that the drug's benefit/risk profile remains positive.

As members of the Seniors Discount Club, it's crucial to be aware of the medications we take and their potential side effects. If you're prescribed Prolia or any other osteoporosis medication, it's vital to have a thorough discussion with your doctor about the risks and benefits. Ask questions, seek second opinions if necessary, and ensure you're comfortable with the treatment plan.

Key Takeaways

• Some Australian patients have raised concerns about not being adequately warned of the side effects of osteoporosis drug Prolia and claim a lack of informed consent.
• Patients have reported serious side effects, including atypical femoral fractures and osteonecrosis of the jaw, as well as severe rebound effects leading to vertebral fractures upon cessation of the drug.
• There are calls for the Therapeutic Goods Administration (TGA) in Australia to issue a black box warning, similar to the one in the United States, to highlight the severe risks associated with the drug.
• While doctors acknowledge that side effects are rare, they stress the risk of serious injury or death from osteoporosis is greater and advise patients not to discontinue treatment without proper advice and alternative measures.

Have you or someone you know been prescribed Prolia? What has your experience been with the medication? Share your stories in the comments below, and let's support each other in making informed health decisions. Remember, knowledge is power, especially when it comes to our well-being.

 

[Penny4]

I've read and heard about the side effects of Prolia. My late mother had the injections for many, many years without any issues. I also know a lot of older women who get the injections without any problems as well. There doesn't seem to be an alternative, however no doubt one day there will be.
The case of Tiffany May getting Prolia at 53 seems young. I'm sure she could have seen an Exercise Physiologist who gives personal exercises to do at home, as well as diet etc. I've seen one and do exercises at home.